Orthopaedic Oncology Program

The Orthopaedic Oncology Program focuses on the treatment of bone and soft tissue tumors. In addition, we provide management for patients with cancers that have spread from other sites to the bones such as the lung, breast, prostate, kidney or thyroid.

Under the direction of Earl W. Brien, MD, the Orthopaedic Oncology Program provides comprehensive evaluation and treatment of malignant and benign bone and soft tissue tumors and metastatic disease. Dr. Brien has published numerous papers on the diagnosis and treatment of these rare tumors. He is recognized both nationally and internationally as a leader in the field of musculoskeletal tumors and continues to educate physicians by lecturing on this topic around the world. He has authored several book chapters in the area of bone and soft tissue tumors as well as osteoporosis.

Dr. Brien has performed thousands of successful surgeries focusing on saving the limb. He also has specialty training in metabolic bone disease such as osteoporosis and complex infections. At Cedars-Sinai, a multidisciplinary team that includes Orthopedic Oncology, Medical Oncology, Radiation Oncology and Pathologist specializes in bone and soft tissue tumors are amongst the finest in the world. Patients are seen in a timely fashion and diagnosis and treatment is rendered promptly as well.


Diagnostic and evaluation services at Cedars-Sinai provide expertise in distinguishing between tumors, infections and metabolic diseases such as Paget's or osteoporosis, which may be difficult to differentiate. Dr. Brien provides diagnostic and treatment expertise in distinguishing between the more than 300 variations of benign and malignant soft tissue tumors that affect children and adults.

Associated with the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, the Orthopaedic Oncology Program provides access to a full range of cancer treatment services. The conditions treated at the Orthopaedic Oncology Program include:

Benign Bone Tumors
  • Aneurysmal bone cyst
  • Unicameral bone cyst
  • Bone island
  • Chondroblastoma
  • Chondromyxoid fibroma
  • Complex infections
  • Enchondroma
  • Enostosis
  • Fibrous dysplasia
  • Giant cell tumor
  • Glomus tumor
  • Hemangioma
  • Histiocytosis
  • Juxtacortical chondroma
  • Nonossifying fibroma
  • Osteoblastoma
  • Osteochondroma
  • Osteofibrous dysplasia
Malignant Bone Tumors
Benign Soft Tissue Tumors
  • Desmoid/fibromatosis
  • Fibroma/elastofibroma
  • Giant cell tumor
  • Hemangioma
  • Lipoma/lipoblastoma
  • Mesenchymoma
  • Myositis ossificans/fascitis/myositis
  • Neuroma/neurofibroma/schwannoma
  • Pigmented villo nodular synovitis (PVNS)
  • Synovial osteochondroma
  • Xanthoma
Malignant Soft Tissue Tumors
  • Angiosarcoma
  • Fibrosarcoma
  • Leimyosarcoma
  • Liposarcoma
  • Malignant fibrous histiocytoma
  • Mesenchymoma
  • Neurogenic sarcoma
  • Rhabdomyosarcoma